Macrophage migration inhibitory factor-deficient mice are resistant to ovariectomy-induced bone loss.

نویسندگان

  • Shigeki Oshima
  • Shin Onodera
  • Norio Amizuka
  • Minqi Li
  • Kazuharu Irie
  • Satoshi Watanabe
  • Yoshikazu Koyama
  • Jun Nishihira
  • Kazunori Yasuda
  • Akio Minami
چکیده

A link between macrophage migration inhibitory factor (MIF) and estrogen has recently emerged. We examined the involvement of MIF in osteoporotic changes in bone after ovariectomy (OVX), and revealed that MIF-deficient mice (MIF-KO) were completely protected from this phenomenon. The increase in osteoclast number per bone surface and serum IL-1beta levels, which were observed in wild-type mice after OVX, did not occur in MIF KO. Our data suggest that MIF plays an important role in the pathogenesis of postmenopausal osteoporosis, and could be a novel target for the treatment of this disease.

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عنوان ژورنال:
  • FEBS letters

دوره 580 5  شماره 

صفحات  -

تاریخ انتشار 2006